重组组织型纤溶酶原激活剂联合尿激酶治疗急性脑梗死的
临床观察
张国鲁;张微微;黄勇华;范慧敏
【期刊名称】《中华老年心脑血管病杂志》 【年(卷),期】2012(014)005
【摘要】objective To observe the long-term effect and safety of combined thrombolytic therapy with low-dose recombinant tissue plasminogen activator(rt-PA) and urokinase(UK) for acute cerebral infarctionC ACI). Methods One hundred and sixty-one ACI patients were randomly divided into combined thrombolysis group (h = 44), rt-PA group (tz = 37) ,UK group (n = 32), and control groupCn = 48). Their NIHSS scores and rates of recurrent infarction, hemorrhage and death were observed before and 90 days after treatment. Results The effect of combined thrombolytic therapy for ACI was significantly better 90 days after treatment than before treatment (P<0. 01). However,no significant difference was observed in its effective and satisfactory rates for ACI between 3 thrombolysis groups and control group 90 days after treatmentP>0. 05). The incidence of intra cerebral hemorrhage was significantly lower in combined thrombolysis group than in rt-PA group and UK group (2. 3% vs 18. 9% and 18. 7%,P<0. 05). Conclusion The long-term effect of combined thrombolytic therapy is similar to that of rt-PA therapy or urokinase therapy for ACI with a low incidence of
重组组织型纤溶酶原激活剂联合尿激酶治疗急性脑梗死的临床观察
