Highly Enantioselective Synthesis of a-Trifluoromethyldi- hydropyrans Using a Chiral Trifl

Highly Enantioselective Synthesis of a-Trifluoromethyldi- hydropyrans Using a Chiral Trifluoroethyl-substituted Thiourea Catalyst

Derived from Amino Acid

李鹏;赵刚;朱仕正

【期刊名称】《中国化学（英文版）》 【年(卷),期】2011(029)012

【摘要】An enantioselective Michael addition of ethyl 4,4,4-trifluoro-3-oxobutanoate to α,β-unsaturated ketone esters using a chiral alkyl-substituted thiourea catalyst is reported. Excellent levels of stereo-induction （up to 98% ee） under mild reaction conditions were obtained to afford the corresponding α-trifluoromethyldihydropyrans. 【总页数】10页(2749-2758)

【关键词】取代硫脲;催化剂;不对称合成;手性;氨基酸;氟取代;衍生;甲酸乙酯 【作者】李鹏;赵刚;朱仕正

【作者单位】Key Laboratory of Synthetic Chemistry of Natural Substances and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China;Key Laboratory of Synthetic Chemistry of Natural Substances and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China;Key Laboratory of Synthetic Chemistry of Natural Substances and Key