Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesench

Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal

Stem Cells by Ultrashort Echo Time Magnetic

Resonance Imaging

Quan Zhou;Shao-Lin Li;Ya-Jun Ma;Vicki de Tal;Wei Li;Ying-Hua Zhao

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2018(131)009

【摘要】Objective:Currently,magnetic resonance imaging (MRI) is the most commonly used imaging modality for observing the growth and development of mesenchymal stem cells (MSCs) after in vivo transplantation to treat osteoarthritis (OA).However,it is a challenge to accurately monitor the treatment effects of MSCs in the zone of calcified cartilage (ZCC) with OA.This is especially true in the physiological and biochemical views that are not accurately detected by MRI contrast agents.In contrast,ultrashort time echo (UTE) MRI has been shown to be sensitive to the presence of the ZCC,creating the potential for more effectively observing the repair of the ZCC in OA by MSCs.A special focus is given to the outlook of the use ofUTE MRI to detect repair of the ZCC with OA through MSCs.The limitations of the current techniques for clinical applications and future directions are also discussed.Data

Sources:Using

the stem

combined cells\

keywords:\

cartilage\\resonance imaging\PubMed/MEDLINE literature search was conducted up to June 1,2017.Study Selection:A total of 132 published articles were initially identified citations.Of the 132 articles,48 articles were selected after further detailed review.This study referred to all the important English literature in full.Results:In contrast,UTE MRI has been shown to be sensitive to the presence of the ZCC,creating the potential for more effectively observing the repair of the ZCC in OA by MSCs.Conclusions:The current studies showed that the ZCC could be described in terms of its histomorphology and biochemistry by UTE MRI.We prospected that UTE MRI has been shown the potential for more effectively observing the repair of the ZCC in OA by MSCs in vivo.

【总页数】7页(1092-1098) 【关键词】

【作者】Quan Zhou;Shao-Lin Li;Ya-Jun Ma;Vicki de Tal;Wei Li;Ying-Hua Zhao

【作者单位】Department of Radiology, Third Affiliated Hospital of Southern Medical University(Academy of Orthopedics Guangdong Province), Guangzhou, Guangdong 510630, China;Department of Radiology,

Third

Affiliated

Hospital

of

Southern

Medical

University(Academy of Orthopedics Guangdong Province), Guangzhou, Guangdong 510630, China;Department of Medical Imaging, The Fifth

Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China;Department of Radiology, University of California, San Diego, CA 92103-8226, USA;Department of Radiology, University of California, San Diego, CA 92103-8226, USA;Department of Radiology, Third Affiliated Hospital of Southern Medical University(Academy of Orthopedics Guangdong

Province),

Guangzhou,

Guangdong

510630,

China;Department of Radiology, Third Affiliated Hospital of Southern Medical University(Academy of Orthopedics Guangdong Province), Guangzhou, Guangdong 510630, China 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-medical-journal_thesis/0201254179479.html 【相关文献】

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