Diet containing seeds of Buchholzia coriacea accelerates healing of acetic acid induced co

Diet containing seeds of Buchholzia coriacea accelerates healing of acetic acid induced colitis in

rats

Tosan P.Omayone;Adeola T.Salami;Adeola O.Odukanmi;Samuel B.Olaleye

【期刊名称】《亚太热带生物医学杂志（英文版）》 【年(卷),期】2018(008)003

【摘要】Objective:To investigate the anti-colitic effects of diet containing seeds of Buchholzia coriacea (B.coriacea) on acetic acid induced ulcerative colitis.Methods:Male Wistar rats (70-100 g) were fed with standard diets (control group) or with same diet containing B.coriacea seeds at 12.5％ or 25％ for six weeks.At the sixth week,colitis was induced by intra-rectal administration of 1 mL/200 g 6％ acetic acid.Animals were sacrificed at days 0 (before induction),1,3 and 7 post induction to assess disease severity via evaluation of stool consistency,haematological variables and histomorphometry of colon tissues.Results:A significant increase in body weight was observed in the 12.5％ B.coriacea fed group compared to the control.B.coriacea significantly

reduced

stool

consistency revealed

and

microscopic decreased

scores.Histological evaluation significantly

inflammatory aggregates in B.coriacea fed groups compared to control after colitis induction.There was a significant decrease in packed cell volume,red blood cell and haemoglobin concentration in the control