Dimedone-catalyzed Addition of Amines into Cyano Group： Facile Synthesis of Thiazol-2-yl

Dimedone-catalyzed Addition of Amines into Cyano Group： Facile Synthesis of Thiazol-2-yl

Substituted E-Acrylonitriles

朱伟军;屠兴超;冯惠;屠蔓苏;姜波;吴飞跃;屠树江

【期刊名称】《中国化学（英文版）》 【年(卷),期】2012(030)007

【摘要】An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and amines. The a-thiocyanate ketones were subjected with malononitrile to provide thiazol-2-ylidenemalononitrile derivatives, followed with various amines in the presence of dimedone to yield the final thiazol-2-yl substituted acrylonitrile derivatives. 【总页数】7页(1617-1623)

【关键词】催化合成;丙烯腈;噻唑;酮;胺;氰基;衍生物;两步反应 【作者】朱伟军;屠兴超;冯惠;屠蔓苏;姜波;吴飞跃;屠树江

【作者单位】School of Chemical Engineering and Technology, Xuzhou College of Industrial Technology, Xuzhou, Jiangsu 221000, China;School of Chemistry and Chemical Engineering, Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China;School of Chemistry and Chemical Engineering, Laboratory of Green Synthetic Chemistry for Functional Materials,