Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with

Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with

Amnestic Mild Cognitive Impairment

Kang Soo Lee;Ji Hyung Chung;Kyung Hye Lee;Min-Jeong Shin;Byoung Hoon Oh;Soo Hyung Lee;Chang Hyung Hong

【期刊名称】《中国免疫学杂志（英文版）》 【年(卷),期】2009(006)002

【摘要】A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI. Cellular & Molecular Immunology. 【总页数】5页(143-147) 【关键词】