妊娠早期孕妇血清中ADAM12-S水平与异位妊娠的相关
性研究
尹爱华;杨洁霞;曾玉坤;吴菁;杜丽;麦明琴
【期刊名称】《实用妇产科杂志》 【年(卷),期】2012(028)006
【摘要】Objective:To explore the possible association of maternal serum levels of disintegrin and met-alloprotease (ADAM12-S) and ectopic pregnancy in the first trimester of pregnancy. Methods: The maternal serum concentration of ADAM12-S from 5 to 9 weeks was measured in 60 cases of ectopic pregnancy and 120 controls matched to the cases by gestational age and length of storage in our hospital from July 2010 to May 2011. ADAM12-S levels were measured by the automated AutoDELFIA immunoassay platform. The relationship between ADAM12-S level and ectopic pregnancy were analyzed. Results:The median levels of ADAM12-S at 5,6,7, 8,9weeks of gestation were 6.80 ±0. 56 μg/L, 17.45 ±1.22 μg/L, 40.24± 2.72 μg/L, 86.64 ±5.31 μg/L, 162.42 ±15.75 μg/L respectively, showing a linear increase with the gestational age ( r=0. 898, P<0. 05). In the control group the concentration of ADAM12-S increased with fetal crown rump length. The multiple of medians (MOMS) of ectopic pregnancy group was significantly lower than those of the control group (P<0.01). Conclusions:There is a good correlation between the maternal serum ADAM12-S and ectopic pregnancy.
妊娠早期孕妇血清中ADAM12-S水平与异位妊娠的相关性研究
