Mutations in the D-loop region of mitochondrial
DNA in gastric cancer
Yibing Zhao;Hongyu Yang;Guoyu Chen
【期刊名称】《生物医学研究杂志（英文版）》 【年(卷),期】2005(019)002
【摘要】Objective: To investigate the mutations in the D-loop region of mitochondrial DNA (mtDNA) in gastric cancer.Methods: The mtDNA of D-loop region was amplified by PCR and sequenced in 20 samples from gastric cancer tissue and adjacent normal membrane. Results: There were 7/20(35% ) mutations in the mtDNA of D-loop region in gastric cancer patients. There were four microsatellite instabilities among the 18 mutations. Nine new polymorphisms were identified in 20 patients. Conclusion: The mtDNA of Dloop region might be highly polymorphoric and the mutation rate is high in patients with gastric cancer. 【总页数】4页(95-98)
【关键词】mitochondrial DNA;D-loop;mutation 【作者】Yibing Zhao;Hongyu Yang;Guoyu Chen
【作者单位】Department of Gastrointestinal Surgery, the First Affiliated Hospital
of
Nanjing
Medical
University,
Nanjing
210029,
China;Department of Gastrointestinal Surgery, the First Affiliated Hospital
of
Nanjing
Medical
University,
Nanjing
210029,
China;Department of Gastrointestinal Surgery, the First Affiliated
Hospital of Nanjing Medical University, Nanjing 210029, China 【正文语种】中文 【中图分类】 【相关文献】
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Mutations in the D-loop region of mitochondrial DNA in gastric cancer
