A Second Dose of GnRHa in Combination with Luteal GnRH Antagonist May Eliminate Ovarian Hy

A Second Dose of GnRHa in Combination with Luteal GnRH Antagonist May Eliminate Ovarian Hyperstimulation Syndrome in Women with≥30 Follicles Measuring≥11 mm in Diameter on Trigger Day and/or Pre-trigger Peak Estradiol Exceeding 10

000 pg/mL

Ling

DENG[1];Xue-Ian

LI[1,2];De-sheng

Blockeel[3];Xing-yu

YE[1];Christophe

ZHOU[1];Shi-ling CHEN[1];Xin CHEN[1];;

【期刊名称】《当代医学科学(英文)》 【年(卷),期】2019(039)002

【摘要】This observational study included 21 patients at remarkably high risk of ovarian hyperstimulation syndrome(OHSS),characterized by more than 30 follicles measuring≥11 mm in diameter on trigger day and/or pre-trigger peak estradiol exceeding 10 000 pg/mL.which was also the feature of women with established severe early OHSS followed by gonadotrophin-releasing hormone agonist(GnRHa)trigger and freeze-all policy that previously have been reported.All patients received a second dose of GnRHa 12 h after the first GnRHa trigger combined with administration of GnRH antagonist at 0.25 mg/day for a period of 3 days from the day of oocyte retrieval onwards.The in vitro fertilization(IVF)outcomes may be preferable compared with a bolus of GnRHa trigger and none of the included patients developed moderate-