Influence of insulin resistance on long-term outcomes in patients with coronary artery dis

Influence of insulin resistance on long-term outcomes in patients with coronary artery disease

after sirolimus-eluting stent implantation

ZHAO Liang-ping;L(U) An-kang;SHEN Wei-feng;LIU Hai-feng;MA Xiao-ye;FAN Xiao-ming;ZHANG Qi

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2010(123)006

【摘要】Background Insulin resistance(IR)is significantly associated with coronary artery disease and cardiovascular events in rnpatients with or without type 2 diabetes mellitus.This study aimed to evaluate the influence of IR on long-term outcomes of rnpatients undergoing percutaneous

coronary

intervention(PCI)with

sirolimus-eluting

stent(SES)implantation.Methods A total of 467 consecutive patients undergoing SES-based PCI were divided into lR group(n=104)and non-IR group(n=363).The patients were followed up for one year.The rate of major adverse cardiac events(MACEs) including death, non-fatal myocardial infarction and recurrent angina pectoris was compared by the log-rank test,and the independent risk factors were identified by the Cox regression analysis.Results MACEs occurred more frequently,and cumulative survival rate was lower in the IR group than in the non-IR group during the follow-up (all P<0.05).IR was an independent risk factor for the occurrence of cardiac death and rnnon-fatal myocardial