CYFRA21-1和CEA对局部晚期非小细胞肺癌患者早期预后的意义

CYFRA21-1和CEA对局部晚期非小细胞肺癌患者早期预

后的意义

张丽娜;么建立;郝殿晋;李洪臣;王术艺;张庆波

【期刊名称】《现代肿瘤医学》 【年(卷),期】2013(021)003

【摘要】Objective: To investigate the value of evaluation indicators of carcinoembryonic

antigen

(CEA)

and

cy-tokeratin

19

fragment( CYFRA21 - 1) as short - term efficacy in patients with advanced non - small cell lung cancer (NSCLC). Methods: The level of serum

CEA

and

CYFRA21

-

1

were

detected

by

electrochemoluminescence immu-noassay in 85 patients with locally advanced non - small cell lung cancer. All statistical analyses were done with software of SPSS14.0. Results:The level of CYFRA21 - 1 and CEA was associated with the therapeutic effect. The level of CEA and CYFRA21 - 1 of patients achieving partial remission (PR) or complete remission ( CR) after treatment were decreased significantly; On the contrary, the level of CEA and CYFRA21 - 1 of patients achieving SD or PD were basically stable or increased. In a multivariate analysis , the level of CEA and CYFRA21 - 1 after one cycle of chemotherapy were confirmed as independent prognostic factors for therapeutic effect. Conclusion; The level of CY-FRA21 - 1 and CEA are associated with the therapeutic effect. Patients may get better prognosis with the