DLL4和VEGF蛋白在大肠癌中的表达及其临床意义
冀俊琴;周建华;刘宝军;包金英
【期刊名称】《现代肿瘤医学》 【年(卷),期】2011(019)006
【摘要】Objective :To study the expression of DLL4 and VEGF in colorectal cancer and normal tissues and the relationship with patients ' clinical characteristics and the correlation between the expressions of DLL4 and VEGF. Methods : Expression of DLL4 and VEGF was detected in 60 cases of colorectal cancer tissues and 21 cases of normal colorectal mucosa tissues by immunohistochemical Envision method. Results : The masculine expression rates of DLL4 and VEGF in colorectal cancer tissues were 75. 0％ and 61. 67％ respectively. The positive expression rates of DLL4 and VEGF in colorectal cancer were higher than in normal colorectal mucosa. The expression of DLL4 and VEGF in colorectal cancer tissues was associated with depth of invasion, lymph node metastasis , distant metastasis and TNM staging closely( P ＜ 0. 05 ) , but not with gender, age, locus, the diameter of tumor and the histological differentiation ( P ＞0. 05 ); The VEGF expression rate in DLL4 positive expression cases was significantly more than DLL4 negative cases. DLL4 had positive correlation with VEGF remarkably( r = 0. 257 ,P ＜ 0. 05 ). Conclusion : The expression of DLL4 and VEGF in colorectal cancer and normal tissues was different. The increased
DLL4和VEGF蛋白在大肠癌中的表达及其临床意义
