Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and

Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda

citrifolia

Suthagar Pillai Piaru;Roziahanim Mahmud;Amin Malik Shah Abdul Majid;Zeyad Daoud Mahmoud Nassar

【期刊名称】《亚太热带医药杂志（英文版）》 【年(卷),期】2012(000)004

【摘要】ABSTRACT Objective:Toinvestigate the anti-angiogenic activity and antioxidant properties ofMyristica fragrans (M. fragrans) (nutmeg) andMorinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.Results:The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with anEC50 value of 181.4 μg/mL and 3 043.0μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity withIC50 of77.64μg/mL

comparing to mengkudu oil which exhibits IC50 of109.30

μg/mL.Conclusion: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs. 【总页数】5页(294-298) 【关键词】

【作者】Suthagar Pillai Piaru;Roziahanim Mahmud;Amin Malik Shah Abdul Majid;Zeyad Daoud Mahmoud Nassar

【作者单位】School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia;School of Pharmaceutical Sciences, Universiti

Sains

Malaysia,

11800

Penang,

Malaysia;School

of

Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia;School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_asia-pacific-tropical-medicine-journal-english_thesis/0201254095910.html 【相关文献】

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