Steroids from the Roots of Asparagus officinalis and Their Cytotoxic Activity

Steroids from the Roots of Asparagus officinalis

and Their Cytotoxic Activity

Xue-Feng Huang; Yu-Ying Lin; Ling-Yi Kong

【期刊名称】《《植物学报（英文版）》》 【年(卷),期】2008(050)006

【摘要】One new (Sarsasapogenin O) and seven known steroids were isolated from the roots of Asparagus officinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis,and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxicities against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells. 【总页数】6页(717-722)

【关键词】Asparagus officinalis; cytotoxic activity; Sarsasapogenin O; steroid.

【作者】Xue-Feng Huang; Yu-Ying Lin; Ling-Yi Kong

【作者单位】Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China 【正文语种】中文 【中图分类】Q94