非小细胞肺癌组织中ERCC1及TUBB3基因mRNA的表
达及其临床意义
冷雪峰;冼磊;陈铭伍;阳诺
【期刊名称】《肿瘤预防与治疗》 【年(卷),期】2012(025)001
【摘要】Objective: To investigate the expression and significance of ERCC1
and
TUBB3
gene
mRNA
in
non-small
cell
lung
cancer(NSCLC )tissues, the adjacent normal tissues and benign tissues, and to explore the correlation between ERCC1 and TUBB3 gene mRNA, and their relationship with clinical and phathological characteristics of NSCLC patients. Methods: Expression of ERCC1 and TUBB3 gene mRNA were detected by reverse transcription-polymerase chain reaction ( RT-PCR ) in 82 NSCLC tissues, 36 adjacent normal tissues and 15 benign tissues. Results: ERCC1 and TUBB3 gene were expressed both in carcinoma, adjacent and benign tissues of NSCLC. The positive expression rate of ERCC1 gene in carcinoma, adjacent and benign tissues of NSCLC patients was 54. 9% ( 45/82 ), 44. 4% ( 16/36 ) and 73. 3% ( 11/15 ) respectively ( P = 0. 165 ) without significant difference. The positive expression rate of TUBB3 gene in carcinoma, adjacent and benign tissues of NSCLC patients was 18. 3%( 15/82 ),2. 8%( 1/36 ) and 93. 3% ( 14/15 ) respectively with significant difference( P = 0. 001 ). The expression of ERCCI gene in adenocarcinoma ( 63. 0% , 34/ 54 )was
非小细胞肺癌组织中ERCC1及TUBB3基因mRNA的表达及其临床意义
