Plasma levels of tissue inhibitor of matrix metalloproteinase-1correlate with diagnosis an

Plasma levels of tissue inhibitor of matrix metalloproteinase-1correlate with diagnosis and

prognosis of glioma patients

LIN Yi;WANG Jiang-fei;GAO Guang-zu;ZHANG Guo-zhen;WANG Fei-long;WANG Yun-jie

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2013(126)022

【摘要】Background There is no validated blood biomarker available for glioma management.Invasive growth is the key feature of glioma.We assessed the clinical usefulness of plasma tissue inhibitor of metalloproteinase 1 (TIMP-1),which has less molecular weight than metalloproteinases,as a potential blood biomarker for glioma.Methods A total of 285 patients and 59 normal subjects were studied.Plasma concentration

of

TIMP-1

was

measured

with

enzyme-linked

immunosorbent assay.Plasma TIMP-1 was compared between normal and glioma patients,between patients with different pathological grades,and between patients with different prognoses.Longitudinal changes in plasma TIMP-1 during treatment were also evaluated.Plasma matrix metalloproteinase (MMP)-9 level was also assayed and its clinical usefulness was compared with that of TIMP-1.Results Plasma TIMP-1 and MMP-9 were both increased in glioma patients compared with normal controls (TIMP-1:P ＜0.001; MMP-9:P=-0.007).Plasma TIMP-1