TNFRSF10A基因多态性与非小细胞肺癌临床病理参数及
预后的相关性
黄惠娟;欧阳学农;赵忠全;余宗阳
【期刊名称】《中国肿瘤临床》 【年(卷),期】2011(038)005
【摘要】Objective: To investigate the clinicopathologic correlation between polymorphisms in the Tumor necrosis factor-Related Apoptosis-Inducing Ligand ( TRAIL ) - Death Receptor 4 ( DR4 ) ( TRAIL-DR4 ) ( named tumor necrosis factor receptor superfamily, member 10a [TNFRSF10A]in National Center for Biotechnology Information [NCBI]) gene ( -972C/T, -397G/T ) and non-small cell lung cancer ( NSCLC ), and to study its potential significance in the prognosis of NSCLC patients.Methods: TNFRSF10A gene ( -972C/T, -397G/T ) genotypes were determined in samples from 92 NSCLC patients using polymerase chain reaction restriction fragment length polymorphisms assay ( PCR-RFLP ).Data were also collected regarding initial treatment, surgical methods, and 3-year follow-up.Unconditional logistic regression model was used to analyze the statistical association between genotypes and clinicopathologic characteristics, adjusting for gender, age and smoking history.The 3-year survival curves of these patients were analyzed by Kaplan-Meier method ( log-rank test ).Cox regression model was used to analyze the factors influencing prognosis of NSCLC, and stratified
TNFRSF10A基因多态性与非小细胞肺癌临床病理参数及预后的相关性
