C-reactive protein is associated with the development of tongue squamous cell carcinoma

C-reactive protein is associated with the development of tongue squamous cell carcinoma

Jianxin Du;Wei Hu;Chengzhe Yang;Yegang Wang;Xiaoying Wang;Pishan Yang

【期刊名称】《生物化学与生物物理学报：英文版》 【年(卷),期】2018(050)003

【摘要】C-reactive protein (CRP) acts as a biomarker reflecting different degrees of inflammation.Accumulating reports have suggested that there

is

a

close

relationship

between

CRP

and

various

cancers.However,the influence of CRP on the development of tongue squamous cell carcinoma (TSCC) remains unclear.The purpose of this study was to investigate the role of CRP in TSCC.The results of immunohistochemical staining and statistical analyses showed that CRP expression was associated with TSCC tumor size,lymph node metastasis and pathological differentiation.Cell Counting Kit-8 (CCK-8) assay revealed that CRP could enhance TSCC cell proliferation in a doseand time-dependent manner.Moreover,with CRP stimulation,proliferating cell nuclear antigen (PCNA) expression patterns presented a notable time-dependent up-regulation.In addition,CRP could enhance the invasion and migration of TSCC cells,as revealed by transwell and woundhealing assays,respectively.Annexin V-FITC/PI staining showed that CRP could protect TSCC cells from starvation-and drug-induced apoptosis.With CRP stimulation,.the protein expression levels of