Ezrin蛋白在胃癌组织芯片中的表达及意义
刘冀龙
【期刊名称】《内蒙古医学院学报》 【年(卷),期】2012(034)005
【摘要】Objective: To investigate the expression of Ezrin protein in gastric carcinoma and its clinicopathologic significance. Methods: The expression of Ezrin protein was detected by EnVision im-munohistochemical method in tissues ?microarry (TMA) including 385 cases of gastric carcinoma (without lymphatic metastasis (n =114) and gastric carcinoma with lymphatic metastasis (n = 271)) and their correlations were also analyzed. Another 40 paraffin-embedded tissue blocks of normal gastric epithelium( >7cm away from the edge of the tumor) were selected as the control group. All patients with gastric cancer were treated surgically and diagnosed histologically, without preoperative chemotherapy or radiotherapy. Results.- The positive expression rates of Ezrin were 64.9% (211+39/ 385)in gastric carcinoma tissues and 5.0% (2/40) in normal tissues, Ezrin protein the expression in gastric cancer was significantly higher than in normal gastric mucosa(P<0. 05) ;16. 6% (57+7/114)in gastric carcinoma tissues without lymph node metastasis and 48. 3% (154+32/271 )in those with lymph node metastasis. Ezrin protein expression was higher in metastatic gastric carcinoma than that in rnprimary gastric carcinoma tissues (P <0.
Ezrin蛋白在胃癌组织芯片中的表达及意义
