In vitro hypoglycemic effects of Albizzia lebbeck and Mucuna pruriens

In vitro hypoglycemic effects of Albizzia lebbeck

and Mucuna pruriens

Mangesh Bhutkar; Satish Bhise

【期刊名称】《《亚太热带生物医学杂志：英文版》》 【年(卷),期】2013(000)011

【摘要】Objective:To verify the antidiabetic potential of stem bark of Albizzia

lebbeck(A.lebbeck)and

seeds

of

Mucuna

prurient(M.pruriens)using various in vitro techniques.Methods:The plant extracts were studied for their effects on glucose adsorption,diffusion amylolysis kinetics and glucose transport across yeast cells.Results:Both the plant extracts adsorbed glucose and the adsorption of glucose increased remarkably with an increase in glucose concentration.No significant(P≤0.05)differences were observed between the adsorption capacities

of

A.lebbeck

and

M.pruriens.In

amylolysis

kinetic

experimental model the rale of glucose diffusion was found to increase with lime from 30 to 180min,and both the plant extracts demonstrated significant inhibitory effects on movement of glucose into external solution across dialysis membrane as compared to control.The retardation of glucose diffusion by A.lebbeck extract was significantly higher(P≤0.05)than M.pruriens.These effects were reflected with higher glucose dialysis retardation index values for A.lebbeck than M.pruriens.The plant extracts also promoted glucose uptake by yeast