尤瑞克林注射液对脑梗死患者血清基质金属蛋白酶9及预
后的影响
付胜奇;张淑玲;嵇朋;张洪涛;张道培
【期刊名称】《中华老年心脑血管病杂志》 【年(卷),期】2011(013)002
【摘要】Objective To investigate the effects of Kallikrein on serum matrix metalloproteinase-9 (MMP-9) and prognosis in patients with cerebral infarction, and to explore the mechanism of Kallikrein in treating ischemic stroke.Methods Fifty patients with cerebral infarction(less than 48 hours from symptom onset) were divided by random,double-blind method into control group and Kallikrein group.Each group was continuously given basal treatment for 14-days,Kallikrein group was given additional Kallikrein treatment(Kallikrein 0.15 PNA iv drip per day).The serum levels of MMP-9 were detected before and after treatment.All patients' nerve function was assessed by National Institutes of Health Stroke Scale(NIHSS) and Barthel Index (BI) at admission and 3 months after admission.Results There was no side effect except decreasing blood pressure in one patient of Kallikrein group.After 14 days of treatment,obvious decrease in serum MMP-9 concentration was seen in both groups compared with before treatment,and Kallikrein group was more significant than control group (P ＜ 0.01).At 3 month after admission, neurological functional deficit
尤瑞克林注射液对脑梗死患者血清基质金属蛋白酶9及预后的影响
