不同途径应用氨甲环酸对初次全髋关节置换术患者有效性
及近期安全性研究
范亚楠;温阳阳;张蕾蕾;李文龙;朱英杰;刘又文
【期刊名称】《中国医药导报》 【年(卷),期】2017(014)021
【摘要】Objective To investigate the application of two different routes of administration of Tranexamic Acid on the blood loss and its safety in patients with initial unilateral total hip arthroplasty (THA).Methods 90 patients with femoral head necrosis who need to undergo initial unilateral THA in He'nan Luoyang Orthopedic Traumatological Hospital were randomly divided into three groups by STATA software from October 2014 to August 2016 in Luoyang Orthopedic Hospital of He'nan.They were group A (staticly drop Tranexamic Acid before 10 minutes of the surgery),group B (injecting Tranexamic Acid after completion of surgery) and group C (without using Tranexamic Acid).The three groups of blood loss,postoperative drainage,invisible blood loss,total blood volume,the number of blood transfusions after surgery,blood transfusion and transfusion rate,the rate of deep vein thrombosis and pulmonary embolism after one week and one month follow-up were compared.Results The quantity of postoperative drainage,invisible blood loss,total blood volume,the number of blood transfusions after surgery,blood transfusion and transfusion rate
differences were statistically significant (P ＜ 0.05) among three groups,and the blood loss in the surgery had no statistically significant difference (P ＞ 0.05).Patients in the group C respectively 2 and 4 days after the surgery in 1 case between limb muscle,vein thrombosis and 2 cases of limb phil superficial vein thrombosis,pulmonary embolism was not occurred,who were timely received symptomatic treatment,with leaving hospital improved,after 1 month reviewing,color Doppler ultrasound prompted that the venous thrombosis had disappeared.The patients of group A and group B had not lower limb venous thrombosis and pulmonary embolism in postoperative 1 week and followed up for 1 month.Conclusion Preoperative intravenous and retrograde injection through the drainage tube application of Tranexamic Acid can significantly reduce the primary unilateral total hip arthroplasty in patients with postoperative blood loss and transfusion rate,and the recent security is a very high,and local injections of Tranexamic Acid is more safe and effective,without postoperative adverse reactions and complications.%目的 探讨氨甲环酸的两种不同用药方式对初次行单侧人工全髋关节置换术患者失血量的影响及其近期安全性.方法 筛选河南省洛阳正骨医院2014年10月—2016年8月因股骨头坏死行初次行单侧人工全髋关节置换术患者90例,运用STATA软件随机分为3组,每组各30例.A组于术前10 min静滴氨甲环酸,B组于术毕注射氨甲环酸,C组不使用氨甲环酸.比较三组患者术中出血量、术后引流量、隐形失血量、总失血量、术后输血人数,输血量及输血率、
术后1周及随访1个月下肢深静脉血栓及肺栓塞的发生率.结果 三组术后引流量、隐形失血量、总失血量、术后输血情况比较,差异均有统计学意义(P＜0.05),术中出血量比较,差异无统计学意义(P＞0.05).C组患者分别于术后第2天和第4天出现1例术肢肌间静脉血栓和1例术肢腓浅静脉血栓,及时给予对症处理,好转出院,术后1个月复查下肢静脉彩超提示血栓消失,所有患者均无肺栓塞发生;A组和B组患者术后1周及随访1个月未发生下肢静脉血栓及肺栓塞.结论 术前静滴和术毕经引流管逆行注射应用氨甲环酸均能够显著减少初次行单侧全髋关节置换术患者的失血量及术后输血率,近期安全性较高,且局部注射氨甲环酸更为安全有效,未发现术后不良反应及并发症. 【总页数】5页(97-100,116)
【关键词】全髋关节置换术;失血量;氨甲环酸;安全性 【作者】范亚楠;温阳阳;张蕾蕾;李文龙;朱英杰;刘又文
【作者单位】河南中医药大学洛阳研究生培养工作部,河南郑州 450046;河南中医药大学洛阳研究生培养工作部,河南郑州 450046;河南省洛阳正骨医院河南省骨科医院髋部损伤二科,河南洛阳471002;河南中医药大学洛阳研究生培养工作部,河南郑州 450046;河南省洛阳正骨医院河南省骨科医院髋部损伤二科,河南洛阳471002;河南省洛阳正骨医院河南省骨科医院髋部损伤二科,河南洛阳471002
【正文语种】中文 【中图分类】R683 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_china-medical-
不同途径应用氨甲环酸对初次全髋关节置换术患者有效性及近期安全性研究
