A novel and facile synthesis of 4-arylquinolin-2(1H)-ones under metal-free conditions

A novel and facile synthesis of 4-arylquinolin-2(1H)-ones under metal-free conditions

Bin Sun,Wen-Peng Mai*,Liang-Ru Yang,Pu Mao*,Jin-Wei Yuan,Yong-Mei Xiao

【摘 要】A B S T R A C T A novel and facile synthesis of 4-arylquinolin-2(1H)-ones without metal catalysis has been developed.This reaction involved cyclization/elimination steps and was performed under metal-free conditions using inexpensive reagents such as NaI,select fluor and KOH.

【期刊名称】中国化学快报（英文版） 【年(卷),期】2015(026)008 【总页数】3

【关键词】Keywords:4-Arylquinolin-2(1H)-one Metal-free Select fluor Synthesis

A R T I C L E I N F O Article history:Received 4 March 2015 Received in revised form 13 April 2015 Accepted 20 April 2015 Available online 14 May 2015 ?2015

Chinese

Chemical

Society

and

Institute

of

Materia

Medica,Chinese Academy of Medical Sciences.Published by Elsevier B.V.All rights reserved.

1.Introduction

The scaffold of quinolin-2(1H)-one is an outstanding structural motif