O~6-METHYLGUANINE-DNA
METHYLTRANSFERASE AND HUMAN CANCER
CHEMOTHERAPY
作者：章扬培;王德文;陈月能;吴英;徐惠英;范国才;白晓彬;王晓明;李洁珣;朱力; 作者机构：Institute of Radiation Medicine;Academy of Military Medical Sciences;Beijing 100850;PRC;Cancer Institute;Chinese Academy of Medical Sciences;Beijing 100021;PRC;;; 来源：中国科学 年：1991 卷：000 期：006
页码：P.675-682 页数：8 中图分类：O6 正文语种：CHI
关键词：O~6-methylguanine-DNA methyltransferase ACNU HeLaS3 cells HeLaMR cells
摘要：Two kinds of human tumor cell strains having different activity of O~6-methylguanine-DNA methyltransferase (O~6-MT) were transplanted into nude mice. Then the mice were inject-ed
intraperitoneally with bifunctional alkylating agent 1--(4--amino--2-methyl--5--pyrimidinyl)methy1-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU). The tumors with low O~6-MTactivity were quickly suppressed or cured. The result suggests that some tumors, if previ-sionally determined with low O~6-MT activity, might be efficiently
O~6-METHYLGUANINE-DNA METHYLTRANSFERASE AND HUMAN CANCER CHEMOTHERAPY
