CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

CXCR4 antagonist AMD3100 attenuates colonic

damage in mice with experimental colitis

无

【期刊名称】《世界胃肠病学杂志：英文版》 【年(卷),期】2010(000)023

【摘要】AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium(DSS)-induced colitis in mice.METHODS:Experimental colitis was induced by administration of 5% DSS for 7 d,and assays performed on intestinal segments from the ileocecal valve to the anus.Colonic morphology was examined by hematoxylin and eosin staining.Colonic cytokines were determined by enzyme-linked immunosorbent ... 【总页数】1页(P.) 【关键词】 【作者】无 【作者单位】 【正文语种】英文 【中图分类】R735.3 【相关文献】

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