紫甘薯花青素对LPS致炎小鼠学习记忆能力的保护作用
孙晓;王正;阮杰;王晓慧;郑元林
【期刊名称】《医学研究杂志》 【年(卷),期】2011(040)011
【摘要】目的 探讨紫甘薯花青素对小鼠学习记忆能力的影响.方法 建立小鼠脑组织慢性炎症模型,紫甘薯花青素连续灌喂,对照组灌喂生理盐水,通过开场测试、一次性被动回避测试两种行为学模型观察小鼠学习记忆能力的变化.结果 通过灌喂PSPC后,PSPC+ LPS组的小鼠与LPS组的小鼠相比,在总路程、速度、理毛、贴壁和站立等4个方面的能力都有显著的升高(P＜0.00l)；记忆保持潜伏期显著增高(P＜0.001).结论 紫甘薯花青素对LPS致炎小鼠学习记忆能力具有保护作用.%Objective To explore the protective influence of purple sweet potato color (PSPC) on the mouse's ability of learning and memory. Methods A model of chronic inflammation tissue of mouse brain was established. Mouse was fed with PSPC continually, and normal saline was used for the control group. The change of mouse's ability on its learning and memory was observed through two behavioral models--open field test,step through test. Results After we feeding mouse with PSPC, compared with LPS group, PSPC +LPS group had a significant better performance on the distance,speed,grooming,rearing/learning (P <0. 001 ) ; and also in memory - keeping incubation period( P <0. 001). Conclusion PSPC has a protective effect on the ability of learning and memory in mouse with LPS induced inflammation.
紫甘薯花青素对LPS致炎小鼠学习记忆能力的保护作用
