多孔P（NIPAm-co-AAm）水凝胶对蛋白质控制释放的研
究
杨桔
【期刊名称】《功能材料》 【年(卷),期】2013(000)021
【摘要】Porous poly (N-isopropylamide-co-acrylamide)[P (NIPAm-co-AAm)]hydrogels were prepared by freezing polymerization method.With bovine serum albumin (BSA)as the model drug,it was loaded into por-ous P (NIPAm-co-AAm)hydrogel by post-fabrication encapsulation technique.The loading efficiency and re-lease ratio of model drug were investigated.The influence of different dry processing method on the controlled drug release properties of the drug-loaded hydrogel was also studied.The results showed that creating an inter-connecting pore structure within the hydrogel matrices was an effective strategy to improve the drug loading ef-ficiency and the cumulative released amount.In vitro BSA release from the hydrogels exhibited that dry pro-cessing method played a dominant role in the controlled drug release properties of P(NIPAm-co-AAm)hydro-gel.The drug-loaded hydrogel with the refrigerator freeze-drying treatment showed better sustained drug re-lease of protein drugs.%采用冷冻聚合法制备了多孔结构的 P(NI-PAm-co-AAm)智能水凝胶，选用牛血清白蛋白(BSA)为模型药物分子，通过后包裹技术负载蛋白质药物，考察了多孔水凝胶中蛋白质药物的载药量和体外释
多孔P(NIPAm-co-AAm)水凝胶对蛋白质控制释放的研究
