负性共刺激分子在脓毒症免疫调理治疗中作用的研究进展

负性共刺激分子在脓毒症免疫调理治疗中作用的研究进展

刘仁洋;康秀文

【期刊名称】《临床急诊杂志》 【年(卷),期】2017(018)009

【摘要】Summary Although antibiotics,ventilator management,liquid recovery strategies and blood glucose control have been widely used in treatment of sepsis,septic shock is still the major cause of death in the intensive care unit (ICU).In USA,medical and nursing expenses associated with sepsis were estimated at $17 billion per year and it was still rising.The immune dysfunction is the major cause of death in patients with sepsis shock.The excessive activation of inflammatory response and the subsequent suppression of immune function can cause severe damage to multiple systemic organ functions including the cardiovascular system,respiratory system,urinary system,etc.This paper summarizes the possible causes and mechanisms of sepsis immune paralysis,the possible pathways of programmed death-1 (PD-1,CD279),T cell immunoglobulin and mucin domain-3 (Tim-3 or HAVCR2),cytotoxic T lymphocyte-associated antigen-4 (CTLA-4,CD152) mediated T-cell immunosuppression,the research direction of negative costimulatory molecules in immunomodulation therapy of sepsis is also prospected. 【总页数】6页(713-718)

【关键词】脓毒症;免疫麻痹;负性共刺激分子