Activity of dihydroartemisinin against Leishmania donovani both in vitro and vivo

Activity of dihydroartemisinin against Leishmania

donovani both in vitro and vivo

马莹;芦殿梅;陆小军;廖琳;胡孝素

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2004(117)008

【摘要】@@ Visceral leishmaniasis (VL), also known as kala-azar, is a vector-borne disease caused by protozoa of the Leishmania donovani complex. It is usually fatal if untreated. Pentavalent antimonials have been the mainstay of treatment for more than 60 years, but these drugs have serious side effects and progressive antimonial resistance.1 Other proven therapeutics such as amphotericin B, pentamidine, and paromomycin are costly without oral formulation and unpleasant side effects.2 Thus, new chemotherapeutic drugs are required to supplement or replace currently available drugs. 【总页数】3页(1271-1273)

【关键词】artemisinins;Leishmania donovani;golden hamster 【作者】马莹;芦殿梅;陆小军;廖琳;胡孝素

【作者单位】Department of Parasitology, School of Preclinical and Forensic

Medicine,

Sichuan

University,

Chengdu

610041,

China;Department of Parasitology, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China;Department of Laboratory Medicine, Huaxi Hospital, Sichuan University, Chengdu

610041, China;Department of Parasitology, School of Preclinical and Forensic

Medicine,

Sichuan

University,

Chengdu

610041,

China;Department of Parasitology, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China 【正文语种】中文 【中图分类】 【相关文献】

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