多囊卵巢综合征患者血清中视黄醇结合蛋白4和中性粒细
胞明胶酶相关脂质载蛋白含量变化的意义
张强;黄友敏;周永勤
【期刊名称】《中国实用医刊》 【年(卷),期】2012(039)022
【摘要】Objective To investigate concentration and clinical significance of serum retinol binding protein 4 (RBP4) and neutrophil gelatinase associated lipocalin (NGAL) in patients with polycystic ovary syndrome(PCOS).Methods Ninety-six PCOS patients and 30 healthy women with body mass index (BMI) ＜25 kg/m2 as controls were recruited.PCOS patients were divided into two groups:50 patients BMI≥25 kg/m2 as obese group; 46 patients BMI ＜25 kg/m2 as non-obese group.The concentrations of RBP4 and NGAL were measured by enzyme-linked immunosorbent assay (ELISA).Results ①Obese and non-obese PCOS group RBP4 and NGAL were higher than control group (t =11.27,8.59,10.75,8.23,P ＜ 0.05),and the RBP4 and NGAL were higher in the obese PCOS group than non-obese PCOS group (t =7.68,7.25,P ＜ 0.05).②Pearson correlatien analysis revealed that the serum levels of RBP4 and NGAL were significantly and positively correlated with BMI and HOMA-IR (P ＜ 0.05) ; The serum levels of RBP4 was positively correlated with NGAL (P ＜ 0.05).Conclusions Chronic inflammation maybe exists in patients with PCOS.RBP4 and NGAL may be a predictor
factor in patients with PCOS.%目的 探讨多囊性卵巢综合征(PCOS)患者血清中视黄醇结合蛋白4(RBP4)和中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的浓度与临床意义.方法 对96例PCOS患者及30例正常对照组患者分别采用酶联免疫(ELISA)法检测血清RBP4和NGAL含量；同时根据体质量指数(BMI)将PCOS患者分为肥胖组50例(BMI≥25 kg/m2)和非肥胖组46例(BMI＜ 25 kg/m2).结果 ①肥胖及非肥胖PCOS患者血清中RBP4和NGAL含量均明显高于正常对照组(￡=11.27,8.59,10.75,8.23,P均＜0.05),肥胖PCOS患者血清中RBP4和NGAL含量均明显高于非肥胖PCOS患者(t=7.68,7.25,P均＜0.05)；②Pearson相关分析显示,RBP4与NGAL、BMI及胰岛素抵抗指数(HOMA-IR)呈正相关(P ＜0.05); NGAL与BMI及HOMA-IR呈正相关(P＜0.05).结论 PCOS患者机体内可能存在着一种慢性炎症状态,可能是引起PCOS患者血清RBP4和NGAL水平的升高的原因. 【总页数】4页(67-70)
【关键词】多囊卵巢综合征;视黄醇结合蛋白4;中性粒细胞明胶酶相关脂质运载蛋白;炎症
【作者】张强;黄友敏;周永勤
【作者单位】277500 山东省滕州市中心人民医院妇产科 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-practical-medicine_thesis/0201255346348.html
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多囊卵巢综合征患者血清中视黄醇结合蛋白4和中性粒细胞明胶酶相
