Effects of simvastatin on early oxidative stress and endothelial function in apolipoprotei

Effects of simvastatin on early oxidative stress and endothelial function in apolipoprotein E-deficient

mice

佚名

【期刊名称】《《生物医学研究杂志（英文版）》》 【年(卷),期】2007(021)006

【摘要】Objective:To investigate the mechanisms that Simvastatin,a 3-ydroxy-3-methylglutaryl inhibitor,plays atherosclerosis Apolipoprotein

an

coenzyme role of mice

in its in

A(HMG-CoA)reductase primary

prevention

effect stage

of in of

important

independently E-deficient

lipid-lowering the

early

atherosclerosis.Methods:Twenty-four 6-week old male apoE-deficient mice were randomly divided into two groups:control group(normal saline)and treatment group[simvastatin(5 mg/(kg·d))].Simvastatin was administered to treatment group mice by gavage and the same volume of normal saline was administered to control group mice by the same method

for

2

or

4

weeks.Total

cholesterol(TC),super-oxide

dismutase(SOD),malondialdehyde(MDA)and serum nitric oxide(NO)were measured by biochemical analysis.Results:There was no significant difference

in

serum

TC

between

control

and

treatment

groups.Compared with the control's,the effects of simvastatin were more signiticant in decreasing serum MDA level(P＜0.01 vs control's at