产生ESBLs和AmpC酶的肠杆菌科细菌检测及耐药性分
析
赵永新;李素敏;张卫群;张铁汉
【期刊名称】《中国抗生素杂志》 【年(卷),期】2012(037)003
【摘要】目的 了解我院产ESBLs和AmpC酶细菌的耐药性.方法 对产ESBLs菌和产生AmpC酶菌进行表型的筛选和确证,测定21种药物的耐药性.结果 268株菌中检查出ESBLs菌136株,检出率50.75％,AmpC酶菌116株,检出率43.28％.单产AmpC酶菌,单产ESBLs菌及产AmpC和ESBLs的菌对青霉素、第二、三代头孢菌素类药物的耐药率明显高于非产酶菌的耐药率,两者相比有显著性差异(P＜0.05),多重耐药及泛耐药常见.结论 ESBLs与Amp酶已成为我院肠杆菌科细菌耐药的主要原因.碳青霉烯类、第四代头孢菌素、哌拉西林/三唑巴坦成为我院治疗院内感染的首选药.%Objective To acquare the drug resistance of ESBLs and AmpC 3-lactamase in Enterobacteriaceae in our hospital. Methods To determine and sort out the phenotype of the Enterobacteriaceae that produced ESBLs and AmpC P-lactamase and detect the drug susceptibility of 21 antibiotics. Results Among 268 isolated strains, 136(50.75%) of them were detected to produce ESBLs, 116(43.28%) cases were detected to produce AmpC |3-lactamase. Drug susceptibility test results show that the resistant rates of single-AmpC-positive strains, single -ESBLs -positive strains, AmpC-positive and ESBLs-positive strains to penicillin, the second and third generations of
cephalosporin drugs were much higher than that of enzyme-negative strains.
There
was
significant
difference
between
two
groups(/><0.05).Multiple resistance and generic drug resistance are common. Conclusion AmpC P-lactamase and ESBLs have been a critical cause of the drug-resistance in Enterobacteriaceae. Carbapenems, the fourth generation cephalosporin, piperacillin sodium and tazobactam sodium can be the first choice to treat nosocomial infections. 【总页数】4页(240-243)
【关键词】肠杆菌科;ESBLs;AmpC酶;耐药性 【作者】赵永新;李素敏;张卫群;张铁汉
【作者单位】新乡医学院第三附属医院检验科,新乡453000;新乡医学院第三附属医院检验科,新乡453000;新乡医学院第三附属医院检验科,新乡453000;新乡医学院第三附属医院检验科,新乡453000 【正文语种】中文 【中图分类】R446.5 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-antibiotics_thesis/0201241646303.html 【相关文献】
1.肠杆菌科细菌ESBLs和AmpC酶检测及耐药性分析 [J], 牛文娟 2.肠杆菌科细菌 ESBLs 和 AmpC 酶检测及耐药性分析 [J], 武晓敏
3.肠杆菌科细菌ESBLs和AmpC酶检测及耐药性分析 [J], 张丹丹; 陆阳; 马良
4.肠杆菌科细菌ESBLs和AmpC酶检测及耐药性分析 [J], 张俊峰; 许现伟 5.耐头孢噻肟肠杆菌科细菌ESBLs和AmpC酶的携带率及耐药性 [J], 刘冬; 徐修礼; 樊新; 孙怡群
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产生ESBLs和AmpC酶的肠杆菌科细菌检测及耐药性分析
