Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells

Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells

郑书岩;符润中;沈征武

【期刊名称】《中国化学（英文版）》 【年(卷),期】2012(030)007

【摘要】We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activities of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.

【总页数】5页(1405-1409)

【关键词】肿瘤细胞;抗增殖作用;合成;异黄酮;Jurkat细胞;K562细胞;Raji细胞;氧化偶联

【作者】郑书岩;符润中;沈征武

【作者单位】School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Departmen of Applied Chemistry, East China University of Sciences and Technology, Shanghai 20000, China;School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Basilea Pharmaceutica China Ltd., Haimen, Jiangsu 226100, China 【正文语种】中文