Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tube

Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis

drugs induced liver injury in rats

Gita Mishra;Hemeshwer Kumar Chandra;Nisha Sahu;Satendra Kumar Nirala;Monika Bhadauria

【期刊名称】《亚太热带医药杂志（英文版）》 【年(卷),期】2018(011)009

【摘要】Objective: To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia (P. daemia) against anti-tuberculosis drugs (ATDs) induced liver injury. Methods: Wistar albino rats were divided into seven groups of six animal in each. The ATDs and P. daemia extract (100, 200 and 400 mg/kg, p.o.) were conjointly administered for 8 weeks and various biochemical, histoarchitectural, ultrastructural studies were performed. Results: Administration of ATDs significantly increased aspartate

aminotransferase,

alanine

aminotransferase,

alkaline

phosphatase, triglycerides, cholesterol, bilirubin and decreased glucose and albumin level. Increased lipid peroxidation and reduction in glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs exposure. Administration of P. daemia extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent

manner. Histological and ultra-structural observations substantiated biochemical findings. Conclusions: P. daemia has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies. 【总页数】8页(518-525) 【关键词】

【作者】Gita Mishra;Hemeshwer Kumar Chandra;Nisha Sahu;Satendra Kumar Nirala;Monika Bhadauria

【作者单位】Toxicology and Pharmacology Laboratory, Department of Zoology, Guru Ghasidas University, Bilaspur, Chhattisgarh, 495009, India;Toxicology and Pharmacology Laboratory, Department of Zoology, Guru

Ghasidas

University,

Bilaspur,

Chhattisgarh,

495009,

India;Toxicology and Pharmacology Laboratory, Department of Zoology, Guru

Ghasidas

University,

Bilaspur,

Chhattisgarh,

495009,

India;Laboratory of Natural Products, Department of Rural Technology and

Social

Development,

Guru

Ghasidas

University,

Bilaspur,

Chhattisgarh, 495009, India;Toxicology and Pharmacology Laboratory, Department

of

Zoology,

Guru

Ghasidas

University,

Bilaspur,

Chhattisgarh, 495009, India 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_asia-pacific-tropical-medicine-journal-english_thesis/0201254088839.html 【相关文献】

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