多聚β-1-6-N-乙酰氨基葡萄糖胺对鲍氏不动杆菌生物膜形
成及耐药的影响
郭海娜;向军
【期刊名称】《中华烧伤杂志》 【年(卷),期】2015(031)001
【摘要】Acinetobacter baumannii has emerged as one of the leading bacteria for nosocomial infections,especially in burn wards and ICUs.The bacteria can easily form biofilm and readily attach to abiotic and biotic surfaces,resulting in persistent biofilm-mediated infections.Being surrounded by selfproduced extracellular polymeric substance (EPS),the microorganisms in biofilm can acquire protective property against detrimental environment and their tolerance toward antibiotics is increased.Poly-β-1-6-N-acetylglucosamine
(PNAG),the
common
constituent of EPS in Acinetobacter baumannii,acts as the key virulence factor and plays a crucial role in biofilm formation process.This review describes the properties and functions of the PNAG and its influence on biofilm formation and drug resistance of Acinetobacter baumannii. 【总页数】3页(45-47)
【关键词】感染;鲍氏不动杆菌;生物膜;抗药性;多聚β-1-6-N-乙酰氨基葡萄糖胺 【作者】郭海娜;向军
【作者单位】200025 上海交通大学医学院附属瑞金医院烧伤整形科;200025 上海交通大学医学院附属瑞金医院烧伤整形科
多聚β-1-6-N-乙酰氨基葡萄糖胺对鲍氏不动杆菌生物膜形成及耐药的影响
