Pharmacokinetic and Pharmacodynamic Efficacies of Continuous versus Intermittent Administr

Pharmacokinetic and Pharmacodynamic Efficacies of Continuous versus Intermittent Administration of Meropenem in Patients with Severe Sepsis and Septic Shock: A Prospective Randomized Pilot

Study

Hui-Ying Zhao;Jian Gu;Jie Lyu;Dan Liu;Yi-Tong Wang;Fang Liu;Feng-Xue Zhu;You-Zhong An

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2017(130)010

【摘要】Background:The antibiotic meropenem is commonly administered in patients with severe sepsis and septic shock.We compared the pharmacokinetic,clinical,and bacteriological efficacies of continuous infusion of meropenem versus intermittent administration in such patients.Methods:Patients admitted to the Intensive Care Unit (ICU) with severe sepsis or septic shock who received meropenem were randomly assigned to either the continuous (n =25) or intermittent groups (n =25).The continuous group received a loading dose of 0.5 g of meropenem followed by a continuous infusion of 3 g/day;the intermittent group received an initial dose of 1.5 g followed by 1 g for every 8 h.Clinical success,microbiological eradication,superinfection,ICU mortality,length of ICU stay,and duration of meropenem treatment were assessed.Serial plasma meropenem concentrations for the first and third