强迫症患者静息态脑功能局部一致性研究
田峰;徐成;崔晓红
【期刊名称】《中华行为医学与脑科学杂志》 【年(卷),期】2010(019)003
【摘要】Objective To explore differences of brain spontaneous activity in resting state between obsessive-compulsive disorder(OCD)and control using function magnetic resonance imaging(fMRI)in order to find the base of neural activity in OCD associated with phathophysiological mechanism.Methods 14 subjects with OCD and 14 sex,age and education-matched controls underwent fMRI scans while resting state.ReHo analyses were used to detect neural spontaneous activity across the whole brain by REST.Two within-group analysis was performed between cases and controls by t-test(P＜0.0002)by SPM5.Results Compared with normal controls,the ReHo of right frontal cortex,right parietal cortex,right insula,left cingulated and left parietal cortex were significantly increased in resting state in OCD(P＜0.0002,unadjusted;k≥10).Conclusion The present result impliate that these regions play importance role in mechanism of pathophysioiogy in OCD.%目的 通过静息态功能磁共振研究未用药强迫症患者基础状态下的自发脑活动特征,探讨强迫症静息状态下的脑神经功能改变.方法 采用功能磁共振成像技术(fMRI),检测静息状态下14例未用药强迫症患者(病例组)、以及14例性别、年龄、受教育程度与患者相匹配的对照(对照组)的自发脑功能活动,并对两组分
强迫症患者静息态脑功能局部一致性研究
