伴少见变异融合基因STAT5b-RARα的急性早幼粒细胞白
血病二例并文献复习
黄菲;屈晓燕;许戟;乔纯;吴汉新;沈文怡
【期刊名称】《白血病·淋巴瘤》 【年(卷),期】2016(025)011
【摘要】Objective To improve the recognition of clinical characteristics and treatment outcome of acute promyelocytic leukemia (APL) with STAT5b-RARα fusion gene. Methods The clinical features, therapeutic effects and prognosis of 2 cases of APL associated with STAT5b-RARα fusion gene were analyzed retrospectively, and the related literature was reviewed. Results Both two patients with positive STAT5b-RARα were resistant to retinoic acid and arsenic trioxide therapy. Subset of this disease also showed higher recurrence tendency. Meanwhile, the relapsed patients still had the potential of no response to chemotherapy. Conclusions Till now, there is no specific treatment for this rare genotype APL. Treatment should be adjusted according to the status of the disease, and hematopoietic stem cell transplantation may improve the prognosis and prolong overall survival.%目的：提高对伴STAT5b-RARα融合基因急性早幼粒细胞白血病（APL）临床特征和治疗转归的认识。方法回顾性分析2例伴有STAT5b-RARα融合基因APL患者的临床特征、治疗效果、疾病预后，并复习相关文献。结果2例伴有STAT5b-RARα融合基因的APL患者对维甲酸和亚砷酸无应答，属于高复发倾向的APL亚群，复发患者接
伴少见变异融合基因STAT5b-RARα的急性早幼粒细胞白血病二例并文献复习
