Effects of esculentoside A on production of
interleukin-1,2,and prostaglandin E2
作者：Zhen-yu XIAO;Qin-yue ZHENG;Yuan-ying JIANG;Bin ZHOU;Ming YIN;Hong-bin WANG;Jun-ping ZHANG
作者机构：Department of Pharmacology, Second Milita ry Medical University, Shanghai 200433;Department of Pharmacology, Second Milita ry Medical University, Shanghai 200433;Department of Pharmacology, Second Milita ry Medical University, Shanghai 200433;Department of Pharmacology, Second Milita ry Medical University, Shanghai 200433;College of Pharmacy, Jiao Tong University, Shanghai 200030, China;Department of Pharmacology, Second Milita ry Medical University, Shanghai 200433;Department of Pharmacology, Second Milita ry Medical University, Shanghai 200433 来源：中国药理学报：英文版 ISSN：1671-4083 年：2004 卷：025 期：006 页码：817-821 页数：5 正文语种：chi
关键词：esculentoside A;interleukin-1;interleukin-2;prostaglandins E;interferon-gamma
摘要：AIM: To investigate the influence of esculentoside A (EsA) on immunological function and its mechanism of antiinflammation. METHODS: Interleukin-1 production was measured by thymocyte co-
stimulating assay; the radioactivity of [3H]arachidonic acid (AA) was used to evaluate the release of AA; prostaglandin E2 production was measured with radioimmunoassay (RIA); IL-2 and IFN-γ were detected by ELISA method. RESULTS: EsA (3-12μmol/L)could potently inhibit the production of IL- 1 and PGE2 from both silent and LPS induced macrophages.EsA had no significant effect on the release of AA from murine macrophages. EsA could inhibit the production of IL-2 from murine lymphocytes induced by ConA, but not affect the production from silent lymphocytes. EsA showed no effect on the production of IFN-γ from both silent and ConA induced lymphocytes. CONCLUSION: EsA could affect the immunological function through inhibiting the production of IL-2 from activated splenocytes and the inhibition of production of IL- 1 and PGE2 might be one of the anti-inflammation mechanisms of EsA.
Effects of esculentoside A on production of interl
