Cytotoxic activity and phytochemical analysis of
Arum palaestinum Boiss.
Mai;Mohammed;Farid;Sameh;Reda;Hussein;Lamiaa;Fawzy;Ibrahim;Mohammed;Ali;El;Desouky;Amr;Mohammed;Elsayed;Ahmad;Ali;El;Oqlah;Mahmoud;Mohammed;Saker;
【期刊名称】《亚太热带生物医学杂志：英文版》 【年(卷),期】2015(000)011
【摘要】Objective: To evaluate the in vitro cytotoxic activity of the fractionated extract as well as isolated compounds of Arum palaestinum Boiss.(A. palaestinum)(black calla lily), and to identify the volatile components which may be responsible for the potential antitumor activity.Methods: A. palaestinum was collected from its natural habitats and subjected to phytochemical analysis for separation of pure compounds. In vitro cytotoxic activity was investigated against four human carcinoma cell lines Hep2, He La, Hep G2 and MCF7 for the fractionated extract and isolated compounds. While, the diethyl ether fraction was subjected to GC–MS analysis as it exhibited the most potent cytotoxic effect to evaluate the active constituents responsible for the cytotoxic activities.Results: Four flavonoid compounds were isolated(luteolin, chrysoeriol, isoorientin,isovitexin) from the diethyl ether and ethyl acetate. The extracts and the pure isolated compounds showed a significant high antiproliferative activity against all investigated cell lines. The GC–MS analysis revealed the separation and
Cytotoxic activity and phytochemical analysis of Arum palaestinum Boiss.
