Efficacy and Safety of Unmanipulated Haploidentical Related Donor Allogeneic Peripheral Bl

Efficacy and Safety of Unmanipulated

Haploidentical Related Donor Allogeneic Peripheral Blood Stem Cell Transplantation in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Li-Ping Dou;Hong-Hua Li;Lu Wang;Fei Li;Wen-Rong Huang;Li Yu;Dai-Hong Liu

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2018(131)007

【摘要】Background:Studies of haploidentical-related donor (HRD) stem cell transplantation using a combination of peripheral blood stem cells (PBSCs) and bone marrow as the graft have reported encouraging results for patients with hematological diseases.However,few studies specifically reported transplantation of only PBSCs from HRDs among patients with relapsed or refractory acute myeloid leukemia (AML).Here,the long-term outcomes and side effects of unmanipulated HRD PBSC transplantation (HRD-PBSCT) for relapsed/refractory AML were analyzed.Methods:We performed a retrospective analysis of the outcomes in relapsed/refractory AML patients who underwent PBSCT from HRDs (n =36).Results:Thirty-one (86.1％) patients in the HRD-PBSCT group achieved platelet recovery.The cumulative incidence of acute graft-versus-host disease (aGVHD) in the HRD-PBSCT group was 40.00％,and the cumulative incidence of grades 2-4 aGVHD in this group was 13.33％.A total of 13 patients in the HRD-PBSCT group had