多靶点治疗儿童狼疮肾炎的疗效观察
王笑秋;殷蕾;茅幼英;黄华;周征宇;周纬
【期刊名称】《中华风湿病学杂志》 【年(卷),期】2014(018)009
【摘要】Objective To explore the efficacy of mycophenolate mofetil-based induction or maintenance therapy for children with lupus nephritis
combined
with
Calcineurin
inhibitors
(cyclosporine
A/tacrolimus) for resistant cases.Methods the clinical data were analyzed
for
10
patients
treated
with
multi-target
therapy
(Glucocorticoid + Mycophenolate mofetile+ Cyclosporine A/Tacrolimus) in Department of Nephrology and Rheumatology from January 2005 to December 2011.Calcineurin inhibitor (Cyclosporine A/Tacrolimus) was added when Mycophenolate mofetil-based induction or maintenance protocol was not satisfactory.The data was analyzed by repeated measures data of ANOVA.Results The SLEDAI score (10.9±3.8 vs 7.9±2.6),24 hours urinary protein quantification [(4.0±2.0) vs (2.2±1.8) g] and ESR [(78±10) vs (54±8) mm/l h] were decreased significantly (P＜0.01),while serum albumin [(29±8) vs (34±8) g/L] and complement C3 level [(0.41±0.20) vs (0.70±0.30) g/L] were increased significantly (P＜0.05).The complete remission rate (CR) was 70％ and the response rate was 90％ in the first 6 month,and the CR was 90％ in the last month.Except 1 case withdrawal,the follow-up period for 9 cases was 24
多靶点治疗儿童狼疮肾炎的疗效观察
