多药耐药基因及其表达产物对非小细胞肺癌化疗疗效影响的Meta分析

多药耐药基因及其表达产物对非小细胞肺癌化疗疗效影响

的Meta分析

韩冰;马列;赵明静;毛世涛;王笑歌

【期刊名称】《现代肿瘤医学》 【年(卷),期】2011(019)012

【摘要】Objective: To evaluate the impact of multidrug resistance - 1 and protein expression on chemotherapy response in non - small cell lung cancer patients with evidence -based medicine methods. Methods: We

electronically

searched

the

Chinese

Academic

Journals

Database( 1990 - 2010 ) and MEDLINE( 1990 - 2010 ), got the randomized controlled trials regarding impact of multidrug resistance-1 and protein expression on chemotherapy response in non-small cell lung cancer patients . A meta-analysis was carried out by collecting information based on inclusion and exclusion criteria from all studies available. Results: The meta - analysis included 8 trials from 176 studies, a total of 301 patients were included in the analysis. Meta - analysis showed: there was statistical significant in response rate between MDR1/P - gp( + ) and MDR1/ P - gp( - ) non - small cell lung cancer patients on chemotherapy, the OR was 0.16( 95% CI 0. 05 - 0. 47 ),P = 0. 001. After further analysis, there was statistical significant in response rate between MDR1/P - gp( + ) and MDR1/ P - gp( - ) non - small cell lung cancer patients on chemotherapy among these studies that quality