Design, Synthesis and Antitumor Activity of Asymmetric Bis(s-triazole Schiff-base)s Bearin
Design, Synthesis and Antitumor Activity of Asymmetric Bis(s-triazole Schiff-base)s Bearing
Functionalized Side-Chain
HU,Guo-Oiang;HOU,Li-Li;XIE,Song-Oiang;HUANG,Wen-Long
【期刊名称】《中国化学（英文版）》 【年(卷),期】2008(026)006
【摘要】1-Amino-2-pyrid-3-yl-5-(2-benzoylethylthio)-s-triazole (1) was condensed with 1-amino-3-mercapto-5-[(un)substituted phenyl]-s-triazoles and subsequently substituted with chloroacetic acid to afford bis-s-triazole sulfanylacetic acid mono-Schiff bases (3a-3e),which were condensed with 9-formylanthracene to produce asymmetric bis(s-triazole Schiff base) sulfanylacetic acids (4a-4e).The structures of new synthesized compounds were characterized by elemental analysis and spectral data,and their in vitro antitumor activity against L1210,CHO and HL60 cell lines was evaluted via the respective IC50 values by methylthiazole trazolium (MTT) assay. 【总页数】5页(1145-1149)
【关键词】s-triazole;bis(Schiff base);synthesis;antitumor activity 【作者】HU,Guo-Oiang;HOU,Li-Li;XIE,Song-Oiang;HUANG,Wen-Long 【作者单位】Institute of Pharmacy,Henan University,Kaifeng,Henan 475001,China;Institute of Pharmacy,Henan University,Kaifeng,Henan 475001,China;Institute of Pharmacy,Henan University,Kaifeng,Henan
475001,China;Center of Drug Discovery,China Pharmaceutical
University,Nanjing,Jiangsu 210009,China 【正文语种】中文 【中图分类】O6 【相关文献】
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Design, Synthesis and Antitumor Activity of Asymmetric Bis(s-triazole Schiff-base)s Bearin
