纤维蛋白原Bβ链七个位点基因单体型与脑梗死的关系
元小冬;除建辉;张楠楠;王淑娟;邓红亮
【期刊名称】《中华老年心脑血管病杂志》 【年(卷),期】2012(014)002
【摘要】Objective To investigate the impact of FibBP-1420G/A,-993C/T, 1689T/G, BsmAIG/ C, I6I/D, 345C/T, HinflA/C polymorphisms and their haplotypes on functional expression of plasma fibrinogen and the relationship of them with cerebral infarction(CI). Methods 859 healthy subjects from Kailuan Group and 90 patients with the first cerebral infarction were enrolled in this study. Blood biochemistry, fibrinogen concentration,
fibrin-monomer
polymerized
velocity(FMPV)
,
absorbance maximum (Amax) and FMPV/Amax were measured. The seven polymorphisms were detected, and common haplotypes were selected to analyze their correlation with CI. Results Only -1420AA genotype frequency of seven loci between CI and control group had significant difference (P<0. 01); the distribution frequecies were statistically significantly different in their common haplotypes of HI, H2,H3, H4,H5 , H6 and H7 between the two groups(χ2 = 110. 47,P<0. 01). In logistic regression analysis of correlative factors to cerebral infarction, FMPV, FMPV/Amax, Hinfl allele, H2 haplotype, H4 haplotype, and H6 haplotypes were selected, respectively ( P < 0. 05) ;the result of multiple stepwise regression analysis showed that using FMPV as
纤维蛋白原Bβ链七个位点基因单体型与脑梗死的关系
