肿瘤患者单次和多次口服替吉奥片的药动学研究
朱仲玲;薛津怀;阎昭;朱莉;刘美君
【期刊名称】《中国肿瘤临床》 【年(卷),期】2011(038)010
【摘要】Objective: To study the single-dose and multiple-dose pharmacokinetics of tegafur, gimeracil, and oteracil potassium tablets in patients with advanced solid tumors.Methods: Ten patients for the single-dose pharmacokinetics study were administrated 60 mg of tegafur, gimeracil, and oteracil potassium tablets.Nine patients for the multiple-dose pharmacokinetics study were given 60 mg of tegafur, gimeracil, and oteracil potassium tablets twice a day for seven consecutive days.The plasma concentrations of tegafur, 5-fluorouracil ( 5-FU ), gimeracil ( CDHP ), and oteracil potassium ( Oxo ) were determined using high-performance liquid chromatography-tandem mass spectrometry.DAS 2.0 was applied to assess the plasma concentration-time data.Results: After single-dose administration, the Cmax and AUC0-t of tegafur were ( 1407 ± 383 ) ng·mL-1 and ( 15403 ± 8439 ) ng·h·mL-1; for 5-FU, ( 128 ± 36 ) ng·mL-1 and ( 539 ± 138 ) ng·h·mL-1; for CDHP, ( 222 ± 93 ) ng·mL-1 and ( 962 ± 390 ) ng·h·ml-1, and for Oxo, ( 33.2 ± 14.6 ) ng·mL-1 and ( 117 ± 64 ) ng·h·mL-1.Comparing single-dose group with multiple-dose group, no significant differences were observed in the pharmacokinetics
肿瘤患者单次和多次口服替吉奥片的药动学研究
