XPA、XPC、XPD、XRCC1基因单核苷酸多态性与急性淋
巴细胞白血病易感性的关系
汤芳芳;陈敏敏;曾一;徐岳一;欧阳建;徐勇;周荣富;周敏;陈兵;张启国;冯秀;张弦
【期刊名称】《中华内科杂志》 【年(卷),期】2011(050)010
【摘要】Objective To study the relationship between polymorphism of genes XPA, XPC, XPD,XRCC1 and susceptibility to acute lymphoblastic leukemia (ALL) in a Chinese population.Methods Polymorphism were determined by a case-control study through matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry method of Mass-ASSAY platform in 114 confirmed ALL cases and 169 age- and sex- matched controls, so as to compare the relationship between differert genotypes and ALL risk.Results Multivariate logistic regression analysis revealed that individuals carrying at least one 23G variant allele(AG/GG genotypes) had a significantly increased risk for ALL (adjusted OR 2.02; 95％ CI 1.08-3.78) compared with the wild-type genotype (23 AA), and evidence that positive interactions between the polymorphisms in XPC C499T and XPA A23G might occur.Furthermore, individuals with both putative risk genotypes had a significantly higher risk (adjusted OR 5.60; 95％ CI 1.57-19.90), compared with those with both wild-genotypes. By contrast, no significant association was observed between the XPD T751G, XRCC1 G399A, C194T pelymorphism
XPA、XPC、XPD、XRCC1基因单核苷酸多态性与急性淋巴细胞白血病易感性的关系
