70例阿达木单抗注射液的药物不良反应报告分析
代菲;储文功
【期刊名称】《中国新药杂志》 【年(卷),期】2013(022)007
【摘要】目的:探讨阿达木单抗注射液所致药物不良反应(ADR)的特点和规律,指导临床合理用药.方法:采用描述性分析的方法对2010年1月-2011年12月呈报至某省药物不良反应监测中心的阿达木单抗注射液导致的70例ADR报告进行汇总分析.结果:70例ADR报告中,男女比例1∶1；发生率较高的年龄组段为30 ～ 39岁(15例,20.43％)和0～9岁(14例,20.00％)；无合并用药情况；皮疹和谷丙转氨酶升高临床表现例数最多,分别为16例和10例；有2例死亡.结论:经文献研究,阿达木单抗注射液上报的ADR报告很少,然而严重的ADR也没有报道,因此应加强此种药物检测,以便合理用药.%To determine the characteristics and regularity of adverse drug reaction (ADR) induced by adalimumab injection so as to guide rational use of drugs. Methods: In 70 patients, adalimumab injection-induced ADRs reported in Adverse Drug Reaction Monitoring Center of a certain province from Jan. 2010 to Dec. 2011 were summarized for analysis by means of classification and description. Results: In the 70 ADR reports , the proportion of male and female was 1: 1 , a higher incidence was found in 30 ? 39 age group and 0 ? 9 age group, and no drug combination was reported. Rash (16 patients) and the rising of glutamic pyruvic transaminase (GPT, 10 patients) were relatively more frequent. Two patients died. Conclusion:
70例阿达木单抗注射液的药物不良反应报告分析
