血管内皮生长因子(VEGF)在非小细胞肺癌中的表达及其与临床病理

血管内皮生长因子（VEGF）在非小细胞肺癌中的表达及其

与临床病理特征的相关性

曾敏;徐利强;严会志;原野男;伍锅

【期刊名称】《现代肿瘤医学》 【年(卷),期】2016(024)021

【摘要】Objective:To investigate the expression of VEGF in non -small cell

lung

cancer

and

its

correlation

with

pathological

characteristics.Methods:All 72 cases of lung cancer tissues 72 cases of lung cancer adjacent tissues and 30 cases of benign lesions were detected by immunohistochemistry.The expression of VEGF was detected by im-munohistochemistry.The correlation between VEGF expression and clinical pathological features and prognosis were compared.Results:The positive expression rate of VEGF in non -small cell lung cancer tissues was 73.61%, 45.83% in the adjacent tissues,and 26.67%

in

benign

lesions,the

difference

was

statistically

significant(P<0.05). VEGF expression was associated with pathological type,lymph node metastasis,TNMstage,tumor size and differentia-tion degree in non -small cell lung cancer(P <0.05).VEGF positive expression and VEGF negative expression in the survival of patients,the difference was statistically significant(P <0.05).Conclusion:VEGF protein is highly ex-pressed in non -small cell lung cancer tissues,and its expression is closely related to the occurrence and development of tumor.The