体温增高对新生大鼠缺氧缺血性脑损伤后学习记忆功能的
影响
刘惠;温晓红;黄会芝;任维华;方文祥;胡闻;李前进
【期刊名称】《中国新生儿科杂志》 【年(卷),期】2013(028)005
【摘要】Objective To investigate the effect of hyperthermia on the ability of spatial learning and memory in the rat model of neonatal hypoxic-ischemia brain damage.Methods Total of 62 7-day-old neonatal Sprague-Dawley
rats,were
divided
into
four
groups
randomly:hyperthermia hypoxiaischemia brain damage group (HHIBD group,n =20 pups),normothermic hypoxia-ischemia brain damage group (NHIBD group,n =20 pups),hyperthermia alone group (H group,n =11 pups) and normothermic group(N group,n =11 pups).Neonatal rats underwent a combination of left common carotid artery ligation and exposure to 8％ oxygen for 60 minutes (n =40 rats).During the 60-minute hypoxic damage,temperature was elevated to 42 ℃ in 20 animals (HHIBD group),and was maintained%目的 探讨体温增高对新生大鼠缺氧缺血性脑损伤(HIBD)后学习记忆功能的影响.方法 新生7日龄SD大鼠62只,随机分为高温HIBD组、常温HIBD组、单纯高温组和常温对照组.高温HIBD组予以42℃缺氧缺血处理,常温HIBD组予以37℃缺氧缺血处理,缺氧时间60 min.单纯高温组置于42℃水浴箱中60 min而不进行缺氧处理,常温对照组不进行任何处理.4周后利用Morris水迷宫实验评估大鼠空间学习记忆能力,
体温增高对新生大鼠缺氧缺血性脑损伤后学习记忆功能的影响
